What is the clinical evidence from this study?

Study design: Case Report. Population: Purulent pericarditis and mycotic aortic arch aneurysm (n=1). Intervention: Ceftriaxone vs. Standard treatment with NSAIDs. Primary outcome: Isolation of Salmonella Typhimurium from pericardial fluid.

What question did this study set out to answer?

This case examines the rare occurrence of purulent pericarditis and mycotic aortic arch aneurysm due to Salmonella Typhimurium in an immunocompromised patient.

January 9, 2026CureusOpen Access

Purulent Pericarditis and Mycotic Aortic Arch Aneurysm Caused by Salmonella Typhimurium: A Rare Case in an Immunocompromised Patient

Q: What does this research mean for the field?

Invasive Salmonella Typhimurium infection can manifest as purulent pericarditis and a mycotic aortic arch aneurysm in an immunocompromised patient. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

This case highlights a rare presentation of invasive Salmonella Typhimurium infection manifesting as purulent pericarditis and a mycotic aortic arch aneurysm in an immunocompromised patient.

Authors

MMMarta Machado CNCatarina Negrão MMMargarida Mourato

Discussion

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Implication

Case report reveals purulent pericarditis and mycotic aortic arch aneurysm in an immunocompromised patient, highlighting critical interventions.

Key Points

This case examines the rare occurrence of purulent pericarditis and mycotic aortic arch aneurysm due to Salmonella Typhimurium in an immunocompromised patient.
Described the case of a 64-year-old woman with systemic lupus erythematosus and corticosteroid therapy.
Monitored her symptoms, including chest pain and fever, alongside laboratory tests and echocardiograms.
Performed urgent pericardiocentesis and administered intravenous ceftriaxone after culture identification.
Isolated Salmonella Typhimurium from pericardial fluid culture.
Identified progressive constrictive pericarditis despite initial improvement.
Underwent complete pericardiectomy and aortic arch replacement due to the risk of aneurysm rupture.

Study Design

Type

Case Report (n=1)

PICO

Population

Purulent pericarditis and mycotic aortic arch aneurysm (n=1)

Intervention / Comparator

Ceftriaxone vs Standard treatment with NSAIDs (2 grams daily)

Primary Outcome

Isolation of Salmonella Typhimurium from pericardial fluid

Limitations

Single patient case report limits generalizability of findings.

Cite This Study

Machado et al. (2025) conducted a case report in Purulent pericarditis and mycotic aortic arch aneurysm (n=1). Ceftriaxone vs. Standard treatment with NSAIDs was evaluated on Isolation of Salmonella Typhimurium from pericardial fluid. This case highlights a rare presentation of invasive Salmonella Typhimurium infection manifesting as purulent pericarditis and a mycotic aortic arch aneurysm in an immunocompromised patient.

synapsesocial.com/papers/69612fe130ef6c21f6853ebe https://doi.org/10.7759/cureus.100198

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Implication

Case report reveals purulent pericarditis and mycotic aortic arch aneurysm in an immunocompromised patient, highlighting critical interventions.

Purulent Pericarditis and Mycotic Aortic Arch Aneurysm Caused by Salmonella Typhimurium: A Rare Case in an Immunocompromised Patient

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Limitations

Cite This Study

Purulent Pericarditis and Mycotic Aortic Arch Aneurysm Caused by Salmonella Typhimurium: A Rare Case in an Immunocompromised Patient

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Limitations

Cite This Study

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