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January 9, 2026Immunological MedicineOpen Access

High-dose intravenous methylprednisolone pulse therapy significantly increased left atrial volume index and peak early diastolic transmitral flow velocity in patients.

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Key result

High-dose intravenous methylprednisolone pulse therapy significantly increased left atrial volume index and peak early diastolic transmitral flow velocity in patients.

Authors

TNTakashi NawataKMKaori MurakawaKGKohei Goda

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Overview

Observational study investigates cardiac dynamics post high-dose steroid therapy, suggesting increased cardiac preload effects.

Key Points

  • To examine the acute effects of high-dose intravenous methylprednisolone on cardiac filling and function.
  • Single-center prospective study
  • Included eight patients receiving high-dose intravenous methylprednisolone
  • Measured plasma levels of brain and atrial natriuretic peptides
  • Conducted echocardiographic evaluations pre- and post-therapy
  • Increased plasma levels of brain and atrial natriuretic peptides (p < 0.001)
  • Left ventricular end-diastolic diameter tended to increase (p = 0.055)
  • Left atrial volume index increased (p < 0.05)
  • Peak early diastolic transmitral flow velocity increased significantly (p < 0.05)
  • Early diastolic mitral annular velocity tended to increase (p = 0.09)

Cite This Study

Nawata et al. (2025) studied this question. High-dose intravenous methylprednisolone pulse therapy significantly increased left atrial volume index and peak early diastolic transmitral flow velocity in patients.

synapsesocial.com/papers/69612fde30ef6c21f6853ea7https://doi.org/10.1080/25785826.2025.2608493
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Also Consider

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  4. 4Methylprednisolone pulse therapy compared with intravenous dexamethasone for severe COVID-19 patients: a randomized clinical trial2025
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