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January 9, 2026Scientific ReportsOpen Access

Association of surrogate indices of insulin resistance with hypertension: a cross-sectional analysis from PERSIAN Dena cohort study (PDCS)

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Key result

TyG-BMI was significantly associated with hypertension in males (OR: 3.53, P < 0.001) and remained predictive in females (OR: 2.0, P = 0.029).

Authors

AHAmirhossein HosseiniBEBehrooz EbrahimzadehKourMJMohammad-Reza Jowshan

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Overview

Cross-sectional analysis reveals strong associations of insulin resistance indices with hypertension in adults, suggesting tailored screening approaches may be beneficial.

Key Points

  • This research aims to explore the association between surrogate indices of insulin resistance and hypertension across different demographic groups.
  • Analyzed data from 1,840 adults aged 35-70 years in the PERSIAN Dena cohort study.
  • Measured eight indices of insulin resistance: TG/HDL-C, VAI, LAP, TyG, TyG-BMI, TyG-WC, METS-IR, and AIP.
  • Used binary logistic regression and ROC curve analyses, adjusting for age, sex, and other confounders.
  • 171 participants (9.3%) were diagnosed with hypertension.
  • Six indices were significantly associated with hypertension in males: TyG-index (OR: 2.58), TyG-BMI (OR: 3.53), TyG-WC (OR: 2.76), VAI (OR: 1.8), LAP (OR: 2.7), METS-IR (OR: 2.5).
  • TyG-BMI had the strongest association with hypertension and highest predictive power (AUC: 0.712).
  • In females, only TyG-BMI showed significant association with hypertension (OR: 2.0).

Cite This Study

Hosseini et al. (2025) studied this question. TyG-BMI was significantly associated with hypertension in males (OR: 3.53, P < 0.001) and remained predictive in females (OR: 2.0, P = 0.029).

synapsesocial.com/papers/69612fde30ef6c21f6853e6dhttps://doi.org/10.1038/s41598-025-28527-z
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