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January 9, 2026Brain and BehaviorOpen Access

Ischemic stroke mortality in the US has declined overall but recent increases from 2014-2023 signal a reversal, particularly among older adults and racial minorities.

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Key result

Ischemic stroke mortality in the US has declined overall but recent increases from 2014-2023 signal a reversal, particularly among older adults and racial minorities.

Authors

RQRameez QasimLMLaiba MuzammilBQBilal Qammar

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Overview

Analysis reveals mortality trends and disparities in ischemic stroke across demographics in the US, suggesting urgent action is needed.

Key Points

  • To analyze mortality trends related to ischemic stroke in the United States over the past fifty years.
  • Analyzed death certificate data from CDC WONDER (1968-2023) using ICD codes
  • Calculated crude and age-adjusted mortality rates (AAMRs) and annual percent changes (APC)
  • Utilized joinpoint regression for statistical analysis
  • Examined demographic factors including age, sex, and race/ethnicity
  • Ischemic stroke mortality decreased significantly from 76.2 to 10.0 per 100,000 population.
  • Mortality rates showed early declines (1968-1982) but increased in recent years (2014-2023).
  • Men had consistently higher AAMRs compared to women but both showed recent upward trends.
  • Racial disparities persisted, with declines for Black and White adults before reversals after 2014.
  • Older adults (≥65 years) faced the highest mortality burden.

Cite This Study

Qasim et al. (2025) studied this question. Ischemic stroke mortality in the US has declined overall but recent increases from 2014-2023 signal a reversal, particularly among older adults and racial minorities.

synapsesocial.com/papers/69612fd930ef6c21f6853de9https://doi.org/10.1002/brb3.71177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stroke Mortality in the United States from 1968 to 2023: A CDC WONDER Analysis2025 · 8 citations
  2. 2Race-based disparities in hemorrhagic stroke mortality with underlying coagulopathies: A CDC-wonder analysis (1999–2020)2025
  3. 3Abstract Wed164: Aging, Alzheimer's, and Stroke: A 25-Year Longitudinal Analysis of U.S. Mortality Trends2025
  4. 4Stroke-Related Mortality Trends Among Tobacco Users in the U.S.: A 21-Year Retrospective Analysis of National Data from the CDC WONDER Database2025 · 6 citations
  5. 5Cerebrovascular Disease-Related Mortality Trends Among Adults in the United States: A Retrospective Population-Based Study2026