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January 9, 2026MedicineOpen Access

Analysis of the association between hemodynamic parameters and 28-day survival in sepsis patients

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Key result

Higher SOFA scores (OR 1.27), elevated lactate (OR 1.52), and lower MAP (OR 0.95) were significantly associated with increased 28-day mortality in sepsis patients.

Authors

TPTingting PanHSHui Sun

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Implication

Retrospective study analyzes hemodynamic parameters' relationship with survival in sepsis patients, suggesting important prognostic indicators.

Key Points

  • This study aims to evaluate the association between hemodynamic measures and 28-day survival rates in sepsis patients.
  • Retrospective observational study design
  • Included 165 sepsis patients admitted to ICU from March 2021 to March 2024
  • Patients categorized into survival and non-survival groups
  • Assessed hemodynamic parameters within 24 hours of ICU admission
  • Utilized logistic regression and ROC curves for analysis
  • Non-survivors presented higher SOFA and APACHE II scores compared to survivors
  • Higher lactate levels were observed in non-survivors
  • Non-survivors had lower mean arterial pressure
  • Key variables identified included SOFA score, MAP, and lactate as significant mortality predictors
  • The predictive model achieved an AUC of 0.851, indicating good predictive value.

Cite This Study

Pan et al. (2026) studied this question. Higher SOFA scores (OR 1.27), elevated lactate (OR 1.52), and lower MAP (OR 0.95) were significantly associated with increased 28-day mortality in sepsis patients.

synapsesocial.com/papers/69612fd630ef6c21f6853d4ehttps://doi.org/10.1097/md.0000000000046090
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