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January 9, 2026Exploration of CardiologyOpen Access

COVID-19 is associated with a sustained cardiovascular burden in patients with pre-existing heart failure, with significant mortality and readmission rates post-infection.

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Key result

COVID-19 is associated with a sustained cardiovascular burden in patients with pre-existing heart failure, with significant mortality and readmission rates post-infection.

Authors

RPRazieh ParizadJHJuniali HatwalABAjit Singh Brar

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Overview

Systematic review reveals sustained cardiovascular burden in heart failure patients post-COVID-19, indicating crucial monitoring need.

Key Points

  • The aim is to evaluate the long-term cardiovascular outcomes of COVID-19 in patients with pre-existing heart failure.
  • Conducted a systematic review of studies published from 2020 to 2025.
  • Included adults with a confirmed diagnosis of heart failure prior to COVID-19.
  • Data extraction focused on demographics, heart failure subtype, cardiovascular outcomes, quality of life, and management approaches.
  • Identified 45 studies meeting inclusion criteria across high-income countries.
  • COVID-19 correlated with increased heart failure symptoms and 28% readmission rate within 12 months.
  • Mortality rate was approximately 18% at 12 months post-COVID-19.
  • HFrEF patients had a 1.4-fold higher readmission risk than HFpEF patients.
  • Vaccination led to about 40% reduction in mortality and major adverse cardiovascular events.

Study Design

Type

Systematic Review (n=12,450)

PICO

P
Population
Heart Failure (n=12,450)
I
Intervention / Comparator
Vaccination vs Unvaccinated individuals
O
Primary Outcome
Long-term mortality and readmission after COVID-19 in heart failure patients — aHR 0.59 (0.55–0.63)

Main Result

Effect estimate: aHR 0.59 (95% CI 0.55–0.63)

Limitations

  • Predominance of observational studies limits causal inference.
  • High heterogeneity in study design and outcome definitions.
  • Most studies from high-income countries limit generalizability to LMICs.

Cite This Study

Parizad et al. (2026) conducted a systematic review in Heart Failure (n=12,450). Vaccination vs. Unvaccinated individuals was evaluated on Long-term mortality and readmission after COVID-19 in heart failure patients (aHR 0.59, 95% CI 0.55–0.63). COVID-19 is associated with a sustained cardiovascular burden in patients with pre-existing heart failure, with significant mortality and readmission rates post-infection.

synapsesocial.com/papers/69612fd330ef6c21f6853d08https://doi.org/10.37349/ec.2026.101284
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COVID-19 and Cardiovascular Complications: A Follow-Up Study from Tertiary Center2025
  2. 2Cardiovascular Sequelae of Long COVID: A Systematic Review of Clinical Manifestations, Biomarkers, and Management Strategies2025
  3. 3Cardiovascular Sequelae of COVID-19 in Adult Population: A Scoping Review2024
  4. 4Cardiovascular and Multisystem Outcomes Identified at Short- and Long-Term Follow-Up After COVID-19 Hospitalization: A Retrospective Cohort Study2026
  5. 5Cardiovascular Complications of COVID-19 Disease: A Narrative Review2025 · 10 citations