What is the clinical evidence from this study?

Study design: Systematic Review. Population: hip fracture surgery (n=1059). Intervention: PENG vs. FICB. Primary outcome: Postoperative pain scores at 6, 12, and 24 h (SMD -0.13, 95% CI -0.36 to 0.10, p=>0.05).

What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

What does this research mean for the field?

There is no clinically meaningful difference in postoperative pain scores between the pericapsular nerve group (PENG) block and the fascia-iliaca compartment block (FICB) at 6, 12, and 24 hours postoperatively in hip fracture surgery patients. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review compares the effectiveness of three peripheral nerve blocks for postoperative pain relief in hip fracture surgery.

January 9, 2026Archives of Orthopaedic and Trauma SurgeryOpen Access

The postoperative analgesic efficacy of three peripheral nerve blocks in hip fracture surgery: a systematic review and meta-analysis of randomised trials

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Key result

There is no clinically meaningful difference in postoperative pain scores between PENG and FICB at 6, 12, and 24 hours postoperatively.

Authors

KVKaja VermazenUniversity of Warwick ANAnna NiblettUniversity of Warwick CTChloe ThomsonOxford University Hospitals NHS Trust

Discussion

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Implication

A systematic review compares analgesic outcomes of three nerve blocks in hip fracture patients, suggesting limited evidence for superiority.

Key Points

This review compares the effectiveness of three peripheral nerve blocks for postoperative pain relief in hip fracture surgery.
Conducted a systematic review and meta-analysis of randomised trials
Reviewed literature from CINAHL, Cochrane CENTRAL, Embase, Medline, and Google Scholar
Included 19 trials with a total of 1059 patients
No significant difference in pain scores between PENG and FICB at 6, 12, and 24 hours
PENG significantly reduced pain scores at 6 hours compared to FNB (P = 0.004)
Opioid consumption was lower in PENG than FICB over 24 hours (P = 0.02)

Study Design

Type

Systematic Review (n=1,059)

PICO

Population

hip fracture surgery (n=1,059)

Intervention / Comparator

PENG vs FICB

Primary Outcome

Postoperative pain scores at 6, 12, and 24 h — SMD -0.13 (-0.36 to 0.10), p=>0.05

Main Result

Effect estimate: SMD -0.13 (95% CI -0.36 to 0.10)

Absolute Event Rate: 2.47% vs 2.6%

p-value: p=>0.05

Limitations

Low to very low evidence quality as per GRADE assessment.
No studies reported time to mobilisation.

Cite This Study

Vermazen et al. (2026) conducted a systematic review in hip fracture surgery (n=1,059). PENG vs. FICB was evaluated on Postoperative pain scores at 6, 12, and 24 h (SMD -0.13, 95% CI -0.36 to 0.10, p=>0.05). There is no clinically meaningful difference in postoperative pain scores between PENG and FICB at 6, 12, and 24 hours postoperatively.

synapsesocial.com/papers/69612fd030ef6c21f6853cba https://doi.org/10.1007/s00402-025-06139-6

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Implication

A systematic review compares analgesic outcomes of three nerve blocks in hip fracture patients, suggesting limited evidence for superiority.

The postoperative analgesic efficacy of three peripheral nerve blocks in hip fracture surgery: a systematic review and meta-analysis of randomised trials

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Limitations

Cite This Study

The postoperative analgesic efficacy of three peripheral nerve blocks in hip fracture surgery: a systematic review and meta-analysis of randomised trials

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider