What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Endothelial dysfunction, biomarkers (ICAM-1, VCAM-1) (n=663). Intervention: Vitamin E supplementation vs. Placebo, no supplementation, or control. Primary outcome: Change in serum VCAM-1 levels (WMD -21.60 ng/ml, 95% CI [-42.00, -1.19], p=0.038).

What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What does this research mean for the field?

Vitamin E supplementation significantly decreases VCAM-1 levels in adults. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

Evaluate the effects of Vitamin E supplementation on endothelial function biomarkers in adults.

January 9, 2026Artery ResearchOpen Access

Effect of Vitamin E Supplementation on Biomarkers of Endothelial Function in Adults: A GRADE-assessed Systematic Review and Dose-Response Meta-Analysis

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Key result

Vitamin E supplementation significantly decreased VCAM-1 levels in adults.

Authors

MKMehdi Karimi SASepideh AbdiBeth Israel Deaconess Medical Center SHS. Sina Hosseini

Discussion

Member takes

Implication

Systematic review assesses vitamin E supplementation's impact on endothelial biomarkers, suggesting varied effectiveness based on dose and individual factors.

Key Points

Evaluate the effects of Vitamin E supplementation on endothelial function biomarkers in adults.
Conducted a systematic search of randomized controlled trials up to October 2025.
Extracted data from eligible trials and analyzed using weighted mean differences.
Used random-effects models for effect size estimation, assessing heterogeneity and publication bias.
Vitamin E significantly reduced VCAM-1 levels by -21.59 ng/ml (p = 0.038).
No significant change in ICAM-1 levels (p = 0.262).
Greater reductions observed in longer trials and certain isoforms (α-tocopherol for ICAM-1, tocotrienol for VCAM-1).

Study Design

Type

Meta-Analysis (n=663)

PICO

Population

Endothelial dysfunction, biomarkers (ICAM-1, VCAM-1) (n=663)

Intervention / Comparator

Vitamin E supplementation vs Placebo, no supplementation, or control (varies (400 IU to 800 IU))

Primary Outcome

Change in serum VCAM-1 levels — WMD -21.60 ng/ml ([-42.00, -1.19]), p=0.038

Main Result

Effect estimate: WMD -21.60 ng/ml (95% CI [-42.00, -1.19])

p-value: p=0.038

Limitations

High heterogeneity for ICAM-1 (I² = 80.6%)
Potential publication bias for ICAM-1
Variability in participant characteristics, doses, and intervention durations.

Cite This Study

Karimi et al. (2026) conducted a meta-analysis in Endothelial dysfunction, biomarkers (ICAM-1, VCAM-1) (n=663). Vitamin E supplementation vs. Placebo, no supplementation, or control was evaluated on Change in serum VCAM-1 levels (WMD -21.60 ng/ml, 95% CI [-42.00, -1.19], p=0.038). Vitamin E supplementation significantly decreased VCAM-1 levels in adults.

synapsesocial.com/papers/69612fd030ef6c21f6853c75 https://doi.org/10.1007/s44200-025-00098-4

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Implication

Systematic review assesses vitamin E supplementation's impact on endothelial biomarkers, suggesting varied effectiveness based on dose and individual factors.