What question did this study set out to answer?

This research aims to examine the initiation of SGLT-2i after first heart failure hospitalization, identifying predictive factors and hospital disparities.

January 9, 2026ESC Heart FailureOpen Access

Early initiation of sodium–glucose co-transporter-2 inhibitors in heart failure patients: a nationwide study

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Key result

SGLT-2i initiation after first heart failure hospitalization increased from 4.8% in 2021 to 28.5% in 2023 but remains highly variable across hospitals.

Authors

PGPaul GautierUniversité Toulouse III - Paul Sabatier MLMargaux LafaurieInserm FBFrédéric BouissetUniversité Toulouse III - Paul Sabatier

Discussion

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Implication

Nationwide study reveals predictors and disparities in sodium–glucose co-transporter-2 inhibitor initiation in heart failure patients, indicating improvement opportunities.

Key Points

This research aims to examine the initiation of SGLT-2i after first heart failure hospitalization, identifying predictive factors and hospital disparities.
Analyzed data from the French National Healthcare Database (SNDS) from 2021 to 2023.
Assessed SGLT-2i initiation in heart failure patients discharged post-hospitalization, excluding prior SGLT-2i users.
Used multilevel logistic regression to identify predictors of initiation and estimated between-hospital variance.
16.1% of patients initiated SGLT-2is following their first heart failure hospitalization.
Higher initiation rates observed in males, patients under 75, those with diabetes, and lower LVEF.
Initiation rates increased from 4.8% in 2021 to 28.5% in 2023.
A significant portion of SGLT-2i initiators came from 25% of hospitals (MOR 1.55).

Cite This Study

Gautier et al. (2026) studied this question. SGLT-2i initiation after first heart failure hospitalization increased from 4.8% in 2021 to 28.5% in 2023 but remains highly variable across hospitals.

synapsesocial.com/papers/69612fd030ef6c21f6853c71 https://doi.org/10.1093/eschf/xvaf009

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Implication

Nationwide study reveals predictors and disparities in sodium–glucose co-transporter-2 inhibitor initiation in heart failure patients, indicating improvement opportunities.

Early initiation of sodium–glucose co-transporter-2 inhibitors in heart failure patients: a nationwide study

Discussion

Member takes

Implication

Key Points

Cite This Study

Early initiation of sodium–glucose co-transporter-2 inhibitors in heart failure patients: a nationwide study

Discussion

Member takes

Implication

Key Points

Cite This Study

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