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January 9, 2026World Journal of CardiologyOpen Access

Patients undergoing transcatheter edge-to-edge mitral valve repair in landmark trials had distinct characteristics but similar mortality and outcomes compared to observational studies.

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Key result

Patients undergoing transcatheter edge-to-edge mitral valve repair in landmark trials had distinct characteristics but similar mortality and outcomes compared to observational studies.

Authors

RKRasha KaddouraZDZainab Atiyah DakhilDADaoud Al-Badriyeh

Discussion

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Overview

Observational analysis reveals no significant changes in outcomes for patients with secondary mitral regurgitation over time, suggesting stability in treatment effectiveness.

Key Points

  • This research aims to compare patient characteristics and outcomes in real-world settings versus landmark trials for mitral valve repair.
  • Conducted a systematic literature search on MEDLINE, EMBASE, and CENTRAL databases.
  • Divided observational studies into two recruitment periods: 2008-2012 and 2013-2018.
  • Compared pooled variables from each period against landmark trials using a random-effects model for statistical analyses.
  • No major variations were observed between the two five-year recruitment periods.
  • Patients in EVEREST had different characteristics compared to observational studies with significant odds ratios reported for atrial fibrillation and MR etiology.
  • COAPT patients showed higher rates of prior myocardial infarction and renal insufficiency in comparison to observational cohorts.
  • MITRA-FR patients had distinct presentations, such as lower rates of atrial fibrillation but higher use of diuretics, without differences in mortality or MR grade.

Cite This Study

Kaddoura et al. (2025) studied this question. Patients undergoing transcatheter edge-to-edge mitral valve repair in landmark trials had distinct characteristics but similar mortality and outcomes compared to observational studies.

synapsesocial.com/papers/696128f644c2cd6c68456c92https://doi.org/10.4330/wjc.v17.i12.110450
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparing mitral transcatheter edge-to-edge repair and surgical intervention in mitral regurgitation: A meta-analysis2026
  2. 2Comparison of meta-analytical estimates between surgical repair and transcatheter edge-to-edge repair for atrial functional mitral regurgitation2025 · 1 citations
  3. 3Influence of mitral regurgitation etiology on long-term survival after successful transcatheter edge-to-edge mitral valve repair (mTEER)2025 · 1 citations
  4. 44-Year Results of a Randomized Controlled Trial of Percutaneous Repair Versus Surgery for Mitral Regurgitation2013 · 444 citations
  5. 5Functional mitral valve regurgitation outcomes by treatment modality: a systematic review and meta-analysis of reconstructed survival data2026