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January 9, 2026World Journal of CardiologyOpen Access

Beta-blockers reduced all-cause mortality by 22% (HR 0.78) and heart failure hospitalizations by 14% (HR 0.86) compared to calcium channel blockers in HFpEF patients.

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Key result

Beta-blockers reduced all-cause mortality by 22% (HR 0.78) and heart failure hospitalizations by 14% (HR 0.86) compared to calcium channel blockers in HFpEF patients.

Authors

MMMoaz MansoorFDFaisal Nabi DeparHTHafiz Usama Talha

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Overview

Compares beta-blockers and calcium channel blockers in heart failure with preserved ejection fraction, suggesting benefits of beta-blockers.

Key Points

  • To compare the effectiveness and safety of beta-blockers vs calcium channel blockers in patients with heart failure with preserved ejection fraction.
  • Simulated data for 4000 HFpEF patients were generated from electronic medical records.
  • Participants included adults initiating beta-blockers or calcium channel blockers with an ejection fraction ≥ 50%.
  • Effectiveness and safety outcomes were evaluated using various statistical analyses, including Cox proportional hazards models and propensity score matching.
  • Beta-blockers showed lower all-cause mortality rates compared to calcium channel blockers (HR 0.78).
  • Heart failure hospitalization rates were also lower for beta-blockers (HR 0.86).
  • Safety profiles indicated more symptomatic bradycardia and drug discontinuation with beta-blockers, while calcium channel blockers had higher rates of hypotension.

Cite This Study

Mansoor et al. (2025) studied this question. Beta-blockers reduced all-cause mortality by 22% (HR 0.78) and heart failure hospitalizations by 14% (HR 0.86) compared to calcium channel blockers in HFpEF patients.

synapsesocial.com/papers/696128f644c2cd6c68456c8bhttps://doi.org/10.4330/wjc.v17.i12.115254
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