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January 9, 2026Scientific ReportsOpen Access

Exploring the association between pulse wave velocity and CKD progression: a longitudinal study in Mashhad, Iran

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Key result

Pulse wave velocity increased significantly with decreasing estimated GFR, showing each unit rise corresponds to a 41.8% decline in eGFR.

Authors

SDSusan DarroudiNVNaiemeh VarastehHYHayder Taha Yaseen

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Implication

Longitudinal study explores pulse wave velocity's impact on chronic kidney disease progression, suggesting implications for kidney health.

Key Points

  • The study aimed to evaluate the correlation between arterial stiffness, measured by pulse wave velocity, and chronic kidney disease progression.
  • Longitudinal study with 787 participants aged 35-65 from the MASHAD cohort study.
  • Participants categorized into four groups based on serum creatinine and estimated GFR levels.
  • Measurements included pulse wave velocity, central augmentation index, and central aortic pressure.
  • Two analytical models were used to assess associations between arterial stiffness markers and CKD stages.
  • Pulse wave velocity increased as estimated GFR decreased, peaking in patients with the lowest GFR.
  • First model showed significant correlation between higher PWV and lower GFR in advanced CKD groups.
  • Second model confirmed the significant correlation between PWV and GFR after adjusting for confounding factors.
  • Each unit increase in PWV correlated with a 41.8% decline in estimated GFR.

Cite This Study

Darroudi et al. (2025) studied this question. Pulse wave velocity increased significantly with decreasing estimated GFR, showing each unit rise corresponds to a 41.8% decline in eGFR.

synapsesocial.com/papers/696128f244c2cd6c68456c82https://doi.org/10.1038/s41598-025-33887-7
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