Key result
DHA significantly reduces the expression and secretion of pro-inflammatory mediators such as MCP-1, IL-6, and CXCL10 in cardiac adipocytes from CAD patients.
Effect estimate: null (95% CI null)
p-value: p=<0.001
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Ex-vivo model demonstrates omega-3 PUFAs reduce inflammation in adipose cells, indicating potential therapeutic effects in atherosclerosis.
Quarta et al. (2026) studied Coronary Artery Disease (CAD) (n=12). Docosahexaenoic acid (DHA) vs. Control (untreated adipocytes) was evaluated on Inflammatory mediator expression and secretion (null, 95% CI null, p=<0.001). DHA significantly reduces the expression and secretion of pro-inflammatory mediators such as MCP-1, IL-6, and CXCL10 in cardiac adipocytes from CAD patients.
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