What question did this study set out to answer?

The aim is to assess the stability of direct oral anticoagulant levels in plasma after 24 hours of varying storage conditions.

January 9, 2026International Journal of Laboratory Hematology

Measuring Direct Oral Anticoagulant Levels in Laboratory Practice: Impact of Different Storage Conditions of Blood Samples

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Key result

DOACs plasma levels remained stable after 24 h storage under various conditions, with median recoveries between 93% and 102%, ensuring accurate clinical interpretation.

Authors

ASAndrea Sorrentino ARAngela Rogolino FCFrancesca Cesari

Discussion

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Implication

Evaluates the stability of direct oral anticoagulant levels in plasma at different storage conditions, suggesting reliable measurement practices in clinical settings.

Key Points

The aim is to assess the stability of direct oral anticoagulant levels in plasma after 24 hours of varying storage conditions.
Enrolled 182 patients on four direct oral anticoagulants (DOACs).
Collected blood samples in duplicate citrated tubes for baseline values.
Processed one tube within 4 hours and stored the other under different conditions.
Measured DOAC concentrations using clotting or chromogenic assays.
Analyzed stability using non-parametric statistics and Bland–Altman analysis.
All DOACs maintained good stability with median recoveries of 93% to 102%.
No significant proportional errors were found.
Minor biases noted for apixaban, rivaroxaban, and edoxaban, but these are unlikely to affect clinical interpretations.
Variability in measurements was generally low, under 7%.

Cite This Study

Sorrentino et al. (2025) studied this question. DOACs plasma levels remained stable after 24 h storage under various conditions, with median recoveries between 93% and 102%, ensuring accurate clinical interpretation.

synapsesocial.com/papers/69609567f6dae357db7c149c https://doi.org/10.1111/ijlh.70042

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January 9, 2026International Journal of Laboratory Hematology

Measuring Direct Oral Anticoagulant Levels in Laboratory Practice: Impact of Different Storage Conditions of Blood Samples

View Full Paper

Ask AI

Bookmark

Key result

DOACs plasma levels remained stable after 24 h storage under various conditions, with median recoveries between 93% and 102%, ensuring accurate clinical interpretation.

Authors

ASAndrea Sorrentino ARAngela Rogolino FCFrancesca Cesari

Discussion

Member takes

Implication

Evaluates the stability of direct oral anticoagulant levels in plasma at different storage conditions, suggesting reliable measurement practices in clinical settings.

Key Points

The aim is to assess the stability of direct oral anticoagulant levels in plasma after 24 hours of varying storage conditions.
Enrolled 182 patients on four direct oral anticoagulants (DOACs).
Collected blood samples in duplicate citrated tubes for baseline values.
Processed one tube within 4 hours and stored the other under different conditions.
Measured DOAC concentrations using clotting or chromogenic assays.
Analyzed stability using non-parametric statistics and Bland–Altman analysis.
All DOACs maintained good stability with median recoveries of 93% to 102%.
No significant proportional errors were found.
Minor biases noted for apixaban, rivaroxaban, and edoxaban, but these are unlikely to affect clinical interpretations.
Variability in measurements was generally low, under 7%.

Cite This Study

synapsesocial.com/papers/69609567f6dae357db7c149c https://doi.org/10.1111/ijlh.70042

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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