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January 8, 2026Scientific ReportsOpen Access

Six-month MACCE occurred in 57.0% of patients with STEMI, significantly higher compared to 26.4% in those without reperfusion therapy.

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Key result

Six-month MACCE occurred in 57.0% of patients with STEMI, significantly higher compared to 26.4% in those without reperfusion therapy.

Authors

AAAbdul Hakim AlkatiriAQAndriany QanithaAMAkhtar Fajar Muzakkir

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Overview

Prospective cohort study evaluates MACCE and predictors in STEMI patients, suggesting improved management strategies.

Key Points

  • To evaluate six-month major adverse cardiovascular and cerebrovascular events (MACCE) among STEMI patients and identify their predictors.
  • Single-centre, prospective observational study
  • Involved STEMI patients from the Makassar Cardiac Centre
  • Utilized consecutive sampling for participant recruitment
  • Primary endpoint was MACCE at hospitalization, 30 days, and 6 months
  • Six-month MACCE occurred in 57.0% of patients
  • Higher six-month mortality without reperfusion therapy (26.4%) compared to PPCI (17.3%) and fibrinolysis (13.7%)
  • Independent predictors of MACCE included age ≥ 60 years, Killip class ≥ 2, anterior MI, renal impairment, medication non-adherence, and hospital stay ≥ 8 days.

Study Design

Type

Cohort (n=365)

Multicenter

No

PICO

P
Population
ST-elevation myocardial infarction (STEMI) (n=365)
I
Intervention / Comparator
reperfusion therapy (PPCI or fibrinolysis) vs no reperfusion
O
Primary Outcome
Major adverse cardiovascular and cerebrovascular events (MACCE) — HR 1.45 (1.03-2.03), p=0.032

Main Result

Effect estimate: HR 1.45 (95% CI 1.03-2.03)

Absolute Event Rate: 57% vs 26.4%

p-value: p=0.032

Limitations

  • Single-center study which may limit generalizability
  • High proportion of late presentations affecting outcome comparisons
  • Absence of coronary angiography data for most patients limiting analyses of lesion severity and outcome relationships.

Cite This Study

Alkatiri et al. (2025) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=365). reperfusion therapy (PPCI or fibrinolysis) vs. no reperfusion was evaluated on Major adverse cardiovascular and cerebrovascular events (MACCE) (HR 1.45, 95% CI 1.03-2.03, p=0.032). Six-month MACCE occurred in 57.0% of patients with STEMI, significantly higher compared to 26.4% in those without reperfusion therapy.

synapsesocial.com/papers/6960877dfa51ca23bb980a0dhttps://doi.org/10.1038/s41598-025-28624-z
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