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January 8, 2026Journal of Clinical MedicineOpen Access

In atrial fibrillation, the left atrial appendage transforms into the main cardiac source of thrombus formation, necessitating radical exclusion strategies to prevent embolic events.

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Key result

In atrial fibrillation, the left atrial appendage transforms into the main cardiac source of thrombus formation, necessitating radical exclusion strategies to prevent embolic events.

Authors

JZJacob ZeitaniELErmal LikajMNMarco Stefano Nazzaro

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Overview

This review highlights anatomical transformations of the left atrial appendage impacting thromboembolic risk in atrial fibrillation, suggesting personalized intervention strategies.

Key Points

  • The aim is to explore the functional role of the left atrial appendage (LAA) in sinus rhythm and its pathological changes in atrial fibrillation (AF).
  • Review of anatomical and physiological function of the LAA in sinus rhythm and AF.
  • Analysis of strategies for anatomical exclusion of the LAA.
  • Assessment of techniques including anticoagulation, device-based exclusion, and surgical closure.
  • The LAA's function is altered in AF, leading to thrombus formation and increased embolic events.
  • Current strategies for LAA exclusion have specific indications and limitations.
  • Personalized approaches may enhance stroke prevention and reduce complications.

Cite This Study

Zeitani et al. (2025) studied this question. In atrial fibrillation, the left atrial appendage transforms into the main cardiac source of thrombus formation, necessitating radical exclusion strategies to prevent embolic events.

synapsesocial.com/papers/6960877dfa51ca23bb9809fchttps://doi.org/10.3390/jcm15010284
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The left atrial appendage arrhythmogenic and thrombogenic substrate2025
  2. 2Residual Surgical Left Atrial Appendage Leaks: Thromboembolic Risk and Anatomy‐Tailored Percutaneous Closure Strategies2026
  3. 3Minimally Invasive Standalone Left Atrial Appendage Occlusion for Atrial Fibrillation: Procedural Approaches and Complications2026
  4. 4Percutaneous Left Atrial Appendage Closure: Current Evidence and Procedural Insights2025 · 1 citations
  5. 5Left Atrial Appendage Occlusion Devices Focused on Complications of Therapy2025