What type of study is this?

This is a Human Clinical Trial study.

What does this research mean for the field?

In participants with left atrial contraction strain <16.5%, the implantable loop recorder (ILR) significantly reduces stroke risk by 62% compared to usual care. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the treatment effect of SCAF screening based on echocardiographic measures of cardiac structure and function.

January 8, 2026Journal of the American Heart AssociationOpen Access

Effects of Atrial Fibrillation Screening According to Echocardiographic Measures of Cardiac Structure and Function: A Post Hoc Analysis of the LOOP Randomized Clinical Trial

Q: What question did this study set out to answer?

To investigate the treatment effect of SCAF screening based on echocardiographic measures of cardiac structure and function.

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Key result

In participants with left atrial contraction strain <16.5%, the ILR significantly reduced stroke risk by 62% (HR 0.38) compared to usual care in a post hoc analysis.

Authors

FOF J Olsen SDSøren Zöga Diederichsen PJPeter Godsk Jørgensen

Discussion

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Overview

Post hoc analysis reveals stroke risk reduction in atrial fibrillation screening based on left atrial strain.

Key Points

To investigate the treatment effect of SCAF screening based on echocardiographic measures of cardiac structure and function.
Post hoc analysis of the LOOP clinical trial.
Participants were randomized to usual care or ILR with SCAF monitoring.
Echocardiography assessed left ventricular size, left atrial volume, and valvular pathology.
Follow-up assessed the primary outcome of stroke or systemic embolism.
1422 participants enrolled, with 354 diagnosed with AF during follow-up.
No standard cardiac measures modified treatment effect.
Lower left atrial contraction strain was associated with reduced primary outcome risk (HR 0.38).
Only 4% developed the primary outcome during a median follow-up of 5.5 years.

Cite This Study

Olsen et al. (2025) studied this question. In participants with left atrial contraction strain <16.5%, the ILR significantly reduced stroke risk by 62% (HR 0.38) compared to usual care in a post hoc analysis.

synapsesocial.com/papers/6960877dfa51ca23bb9809e0 https://doi.org/10.1161/jaha.125.041184

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January 8, 2026Journal of the American Heart AssociationOpen Access

Effects of Atrial Fibrillation Screening According to Echocardiographic Measures of Cardiac Structure and Function: A Post Hoc Analysis of the LOOP Randomized Clinical Trial

View Full Paper

Ask AI

Bookmark

Key result

In participants with left atrial contraction strain <16.5%, the ILR significantly reduced stroke risk by 62% (HR 0.38) compared to usual care in a post hoc analysis.

Authors

FOF J Olsen SDSøren Zöga Diederichsen PJPeter Godsk Jørgensen

Discussion

Member takes

Overview

Post hoc analysis reveals stroke risk reduction in atrial fibrillation screening based on left atrial strain.

Key Points

To investigate the treatment effect of SCAF screening based on echocardiographic measures of cardiac structure and function.
Post hoc analysis of the LOOP clinical trial.
Participants were randomized to usual care or ILR with SCAF monitoring.
Echocardiography assessed left ventricular size, left atrial volume, and valvular pathology.
Follow-up assessed the primary outcome of stroke or systemic embolism.
1422 participants enrolled, with 354 diagnosed with AF during follow-up.
No standard cardiac measures modified treatment effect.
Lower left atrial contraction strain was associated with reduced primary outcome risk (HR 0.38).
Only 4% developed the primary outcome during a median follow-up of 5.5 years.

Cite This Study

synapsesocial.com/papers/6960877dfa51ca23bb9809e0 https://doi.org/10.1161/jaha.125.041184

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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