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January 6, 2026Open Access

The Effect of High-Intensity Interval Training on the Expression of PI3K and AKT1 Genes in the Skeletal Muscle of Type 2 Diabetic Rats

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Authors

MRMojtaba Ramezani

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Overview

Intervention shows improved insulin sensitivity in type 2 diabetic rats, suggesting benefits of HIIT.

Key Points

  • The study aims to examine the effects of HIIT on PI3K and AKT1 gene expression in muscle of diabetic rats.
  • Twenty-eight male Wistar rats were divided into four groups: healthy control, healthy training, diabetic control, diabetic training.
  • Type 2 diabetes was induced via intraperitoneal injection of streptozotocin.
  • The training groups underwent HIIT on a treadmill for six weeks, five sessions per week.
  • Gene expression was measured using Real-Time PCR and analyzed with one-way ANOVA.
  • HIIT significantly increased PI3K and AKT1 gene expression in diabetic training rats compared to controls (p<0.05).
  • A non-significant increase was noted in healthy control and training groups.

Cite This Study

Mojtaba Ramezani (2025) studied this question.

synapsesocial.com/papers/695d856e3483e917927a51cahttps://doi.org/10.82496/nrmsh.2025.1228614
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