What question did this study set out to answer?

To highlight a rare case of aggressive childhood-onset minimal change disease that progressed to end-stage renal disease.

When Minimal Becomes Massive: A Case Report of Childhood-Onset Minimal Change Disease Marching to End Stage Renal Disease Despite Modern Immunotherapy

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Case report describes a rare progression of minimal change disease in a child, indicating the challenges of treatment.

To highlight a rare case of aggressive childhood-onset minimal change disease that progressed to end-stage renal disease.
Case report of a 31-year-old male diagnosed at age 2.5 with nephrotic syndrome.
Multiple biopsies confirmed minimal change disease with normal glomeruli and effaced podocyte processes.
The patient underwent prolonged corticosteroid therapy and immunosuppressants, including cyclosporine and Rituximab.
The patient progressed to end-stage renal disease and began maintenance hemodialysis.
Developed ischemic stroke at age 20.
Case illustrates an atypical aggressive phenotype of minimal change disease without evolving to focal segmental glomerulosclerosis.

Zetawi et al. (2026) studied this question.

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View Full Paper

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Authors

Case report describes a rare progression of minimal change disease in a child, indicating the challenges of treatment.

To highlight a rare case of aggressive childhood-onset minimal change disease that progressed to end-stage renal disease.
Case report of a 31-year-old male diagnosed at age 2.5 with nephrotic syndrome.
Multiple biopsies confirmed minimal change disease with normal glomeruli and effaced podocyte processes.
The patient underwent prolonged corticosteroid therapy and immunosuppressants, including cyclosporine and Rituximab.
The patient progressed to end-stage renal disease and began maintenance hemodialysis.
Developed ischemic stroke at age 20.
Case illustrates an atypical aggressive phenotype of minimal change disease without evolving to focal segmental glomerulosclerosis.

Zetawi et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark