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Investigate how hybridization affects meat production performance in sheep through transcriptomic and metabolomic analysis.

January 6, 2026AnimalsOpen Access

Integrated Transcriptomic and Metabolomic Analysis Reveals the Meat Production Features in Hybrid Sheep

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Analysis demonstrates improved carcass weight and muscle fiber characteristics in hybrid sheep, suggesting metabolic synergy.

Investigate how hybridization affects meat production performance in sheep through transcriptomic and metabolomic analysis.
Analyzed 36 male lambs of Suffolk, Hu, and their F1 hybrids over a 95-day trial under controlled nutrition and management.
Collected Longissimus dorsi samples and assessed production performance and muscle fiber characteristics.
Conducted differential analysis for genes and metabolites related to muscle and fat metabolism.
SH sheep showed significantly higher carcass weight than Hu sheep but lower than Suffolk sheep (p < 0.05).
Muscle fiber density in SH group was significantly higher than in parental breeds.
Transcriptomic analysis revealed 2920 differentially expressed genes predominantly in AMPK, PI3K-Akt, and PPAR pathways.

Chen et al. (2026) studied this question.

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