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January 6, 2026COVIDOpen Access

Structural Variants in Severe COVID-19: Clinical Impact Assessment

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Authors

JKJohanna KämpeJEJesper EisfeldtPNPer Nordberg

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Overview

Clinical impact assessment shows copy number variants affect renal function in severe COVID-19 patients, suggesting limited role for genetic screening.

Key Points

  • This research aims to evaluate the clinical significance of structural variants in patients with severe COVID-19.
  • Involved a cohort of 301 ICU-treated COVID-19 patients in Sweden.
  • Conducted whole exome sequencing to identify copy number variants and single-nucleotide variants.
  • Analyzed the impact of these variants on relevant clinical parameters.
  • Identified 11 rare copy number variants potentially linked to severe COVID-19.
  • Patients with copy number variants exhibited impaired renal function at ICU admission.
  • Found a significant difference in the heart failure marker NT-proBNP between patients with and without CNVs.

Cite This Study

Kämpe et al. (2026) studied this question.

synapsesocial.com/papers/695d85543483e917927a49echttps://doi.org/10.3390/covid6010010
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