Fucus vesiculosus L. (Bladderwrack) modulates oxidative stress and inflammation on high-fat diet induced obesity in mice
View Full Paper
Ask AI
Bookmark
Share
Discussion
Loading...
Member takes
Implication
Experimental study shows hepatoprotective effect of Fucus vesiculosus against obesity-related liver injury in C57BL/6J mice, indicating beneficial roles in inflammation and oxidative stress.
Key Points
To investigate the hepatoprotective effect of Fucus vesiculosus L. on high-fat diet induced obesity in mice.
Forty male C57BL/6J mice were divided into four groups: control, HFD, Fv, and HFD + Fv.
Fucus vesiculosus was administered at 575 mg/kg body weight/day for 6 weeks orally.
Body weight, liver enzymes, lipid profile, oxidative stress markers, inflammatory cytokines, and liver histopathology were evaluated.
Fucus vesiculosus improved biochemical parameters and alleviated liver steatosis.
Body weight gain was regulated in HFD mice supplemented with Fv.
It downregulated the expression of SREBP-1c, fatty acid synthase, TNF-α, and IL-6 genes.