Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 19, 2025Open Access

Gene positive vs. gene negative clinical and structural outcomes in hypertrophic cardiomyopathy patients: a meta-analysis and systematic review

View Full Paper
Ask AI
Bookmark
Share

Authors

MLM LangeMLMay Li-JedrasCTCorinna Brown Ton

Discussion

Loading...

Member takes

Overview

Meta-analysis reveals increased ventricular arrhythmias in gene positive hypertrophic cardiomyopathy, suggesting refined risk assessment is needed.

Key Points

  • This research aims to clarify the associations between genetic status and clinical outcomes in hypertrophic cardiomyopathy.
  • Conducted a systematic literature search in PubMed for relevant studies.
  • Defined gene positive hypertrophic cardiomyopathy with specific mutations in MYBPC3, MYH7, TNNT2, and TNNI3.
  • Analyzed data using risk ratios and mean differences via random-effects models.
  • Gene positive patients showed significantly increased risk of ventricular arrhythmias.
  • No significant differences were observed in rates of stroke or sudden cardiac death between groups.
  • Findings highlight the importance of genetic mutations in arrhythmic risk and left atrial remodeling.

Cite This Study

Lange et al. (2025) studied this question.

synapsesocial.com/papers/69449a892f0218eca95083b1https://doi.org/10.64898/2025.12.16.25342182
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genotype-Phenotype Relationship in Hypertrophic Cardiomyopathy2025 · 3 citations
  2. 2Genetic, Clinical, and Sociodemographic Profile of Individuals with Diagnosis or Family History of Hypertrophic Cardiomyopathy: Insights from a Prospective Cohort2025 · 2 citations
  3. 3Genetic insights into hypertrophic cardiomyopathy: pathogenesis, diagnosis, and therapeutic implications2025 · 9 citations
  4. 4Impact of genotype on histopathology and clinical characters in a Chinese cohort with obstructive hypertrophic cardiomyopathy2026
  5. 5Genetic and Gender Influences on Hypertrophic Cardiomyopathy: A Comprehensive Population-based Study of Clinical Outcomes and Implications2025