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December 16, 2025Endocrine RegulationsOpen Access

Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes

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Authors

TKTamara KuchmerovskaLYLesya YanitskaOHOksana Horkunenko

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Overview

Combined treatment with acetyl-L-carnitine and alpha-lipoic acid improves glycemic control and reduces hemostatic abnormalities in diabetes, indicating benefits for cardiovascular complications.

Key Points

  • Glycemic control improves as combined treatment lowered blood glucose levels by 1.3-fold.
  • Fibrinogen and factor X levels were significantly altered, indicating metabolic abnormalities in diabetic rats.
  • Analysis involved diabetic Wistar rats treated with acetyl-L-carnitine, alpha-lipoic acid, and nicotinamide for 2 weeks.
  • Findings suggest mitochondria-targeting compounds could be a safe therapy for diabetes-related cardiovascular complications.

Cite This Study

Kuchmerovska et al. (2025) studied this question.

synapsesocial.com/papers/6940acbe3507a57a7f7a43b4https://doi.org/10.2478/enr-2025-0028
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