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December 8, 2025Blood

Beyond mutations: RNA editing deaminase activation as a dynamic marker to track stem cell fitness and MPN progression

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Authors

IWInge van der WerfKWKendale Wirtjes

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Overview

Observational analysis reveals increased deaminase activity and cytokine levels in myeloproliferative neoplasms, suggesting biomarker potential for cancer stem cell progression.

Key Points

  • Dynamic marker identified for disease progression, highlighting ADAR1 expression in cancer stem cells.
  • Next-generation sequencing analyses showed varied genetic mutations in acute myeloid leukemia and myeloproliferative neoplasms patients.
  • Increased cytokine levels correlate with stem cell fitness, indicating potential therapeutic targets for MPN management.
  • Cytokine activity and RNA editing biomarkers can guide predictions in acute myeloid leukemia and stem cell disorders.

Cite This Study

Werf et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5adhttps://doi.org/10.1182/blood-2025-5543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peripheral blood-based single-cell and genomic profiling of hematopoietic stem and progenitor cells enables accurate diagnosis and risk stratification in myeloproliferative neoplasms2025
  2. 2Digital PCR-based dynamic monitoring of JAK2V617F burden: A decade-long study unravels its prognostic value in MPN treatment response2025
  3. 3A rapid gene expression profiler predicts tumor responsiveness and patient outcome for standard-of-care therapies in acute myeloid leukemia2025 · 1 citations
  4. 45-azacytidine treatment reshapes clonal structure and alters mutation-dependent splicing in MDS patients2025
  5. 5Functional annotation of MPN clones reveals mutation-specific fitness and fate bias2025