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December 8, 2025BloodOpen Access

Impact of voxelotor discontinuation on patients with sickle cell disease

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Retrospective study finds hemoglobin decline post voxelotor discontinuation in sickle cell disease, suggesting need for monitoring.

Discontinuation of voxelotor was linked to a notable decline in hemoglobin levels among patients.
Hemoglobin dropped from 8.2 g/dL to 7.7 g/dL following the withdrawal, showing a significant result.
Retrospective analysis of 73 adults provided insights into ED visits and hospitalizations related to SCD.
Highlights the critical need for monitoring and alternative treatments after sudden discontinuation of therapies.

Robert E. Molokie (2025) studied this question.

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