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December 8, 2025Blood

Multi-omics analysis identifies neutrophil degranulation as a PSMD3-regulated pathway in FLT3-mutated AML

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Authors

SDSaeedeh DarvishiSSSharon SibyMBM.M. Black

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Overview

Multi-omics analysis shows PSMD3 regulates neutrophil degranulation in AML, indicating potential therapeutic targets.

Key Points

  • PSMD3 knockdown decreased colony formation in both sensitive and resistant MOLM-14 cells, marking a significant finding.
  • Analysis revealed Aurora kinases were dysregulated while profiling metabolic changes post-PSMD3 knockdown.
  • Single-cell RNA sequencing identified neutrophil degranulation as a key dysregulated pathway in AML.
  • Findings suggest targeting PSMD3 may enhance responses in FLT3-mutated acute myeloid leukemia.

Cite This Study

Darvishi et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e511https://doi.org/10.1182/blood-2025-6757
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