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December 8, 2025Blood

Prevalence and mortality of infections following CAR T-cell therapy in children, adolescents, and young adults: A systematic review and meta-analysis

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Authors

MMMichael MarkKOKonstantinos OuranosJPJenny H. Petkova

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Overview

Systematic review reveals high prevalence of infections post CAR T-cell therapy in young patients, indicating a critical need for better management strategies.

Key Points

  • Infections occurred in 41% of patients following CAR T-cell therapy, with significant risks highlighting the need for targeted intervention.
  • Bacterial infections were most common, with Escherichia coli and Enterococcus faecalis frequently reported, and 22% had severe infections.
  • Analysis included 13 studies with a total of 582 CAYA patients treated for acute lymphoblastic leukemia and revealed a 3% infection-related mortality rate.
  • The findings emphasize the importance of improving infection prevention strategies to enhance survival rates for this vulnerable population.

Cite This Study

Mark et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4d3https://doi.org/10.1182/blood-2025-6851
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Severe infections after CD19-directed chimeric antigen receptor T-cell therapy for Relapsed/Refractory large B-cell lymphoma, a retrospective real-life study from the DESCAR-T registry (LYSA)2025
  2. 2Cytopenias and infectious complications following CD19-directed CAR-T cell therapy in patients with B-ALL: A single-center retrospective analysis2025
  3. 3Infectious complications after CAR T-cell therapy: mechanisms, risk stratification, and prevention2026 · 1 citations
  4. 4Infectious Complications Following CD30 Chimeric Antigen Receptor T-cell Therapy in Adults.2025 · 1 citations
  5. 5Fungal infections following chimeric antigen receptor T-cell (CAR-T) cell therapy: A retrospective case-control study in the south-central US2025