Impact of extranodal involvement in stage I aggressive B-cell lymphoma in the rituximab era: An individual patient data meta-analysis of two Phase III dshnhl/GLA trials
Meta-analysis reveals that extranodal involvement does not worsen clinical outcomes in stage I large B-cell lymphoma, suggesting targeted approaches are needed.
Key Points
Extranodal involvement in stage I large B-cell lymphoma does not correlate with inferior overall survival.
Clinical outcomes indicate that planned radiotherapy does not significantly improve progression-free survival in extranodal cases.
Multivariate analyses accounted for several factors, including bulky disease and treatment arm, enhancing understanding of survival metrics.
The findings suggest that routine radiotherapy may be unnecessary for extranodal stage I lymphoma except in specific cases like testicular involvement.
Cite This Study
Christofyllakis et al. (2025) studied this question.