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December 8, 2025BloodOpen Access

Keeping it renal: Results of applying guideline-based management in sickle cell nephropathy

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Retrospective analysis reveals guideline adherence in managing albuminuria in sickle cell anemia patients, indicating a need for improved therapies.

Patients with sickle cell anemia showed a significant occurrence of albuminuria, with 143 out of 255 diagnosed with microalbuminuria.
Among those with elevated urine albumin, ACEi/ARBs were prescribed in 85 cases, leading to short-term improvements in kidney function.
Retrospective analysis demonstrated that persistent albuminuria was prevalent in 80.9% of patients, correlating with chronic kidney disease stages.
Findings highlight a potential gap in long-term efficacy of ACEi/ARB therapy in sickle cell nephropathy, suggesting further investigation is needed.

Wernecke et al. (2025) studied this question.

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Retrospective analysis reveals guideline adherence in managing albuminuria in sickle cell anemia patients, indicating a need for improved therapies.