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December 8, 2025BloodOpen Access

A prognostic model integrating disease‑ and patient‑oriented factors identifies poor‑outcome patients with low‑risk MDS: A multicenter real‑world cohort study (KOTOSG)

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Authors

TNTakahisa NakamuraHOHaruya OkamotoTTTaku Tsukamoto

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Overview

Observational analysis identified prognostic factors in low-risk myelodysplastic syndromes, indicating improved survival predictions with a new model.

Key Points

  • KPSS-L stratified patients into good, intermediate, and poor-risk categories based on overall survival outcomes.
  • Median overall survival varied significantly among groups: 120.1, 51.2, and 15.7 months, respectively.
  • LASSO-penalized Cox model developed using 1,000 bootstrap resamples identified key prognostic factors.
  • Enhancing traditional models with inflammatory and nutritional markers improves prognostic accuracy for LR-MDS.

Cite This Study

Nakamura et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e422https://doi.org/10.1182/blood-2025-5633
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