What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

December 8, 2025BloodOpen Access

Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial from India

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Authors

PSParas SatadeveAll India Institute of Medical Sciences Rishikesh MKMayank KapoorSwami Rama Himalayan University

Discussion

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Implication

Randomized controlled trial compares consecutive and alternate day high-dose cytarabine schedules in AML, suggesting improved recovery and reduced hospital stay.

Key Points

HiDAC-123 significantly reduced median time to neutrophil recovery compared to HiDAC-135, indicating quicker responses.
Patients in the HiDAC-123 group had shorter hospitalization duration, averaging 14.5 days against 18.5 days with HiDAC-135.
The HiDAC-123 regimen required fewer G-CSF doses and fewer platelet transfusions, which may improve treatment compliance.
There were no significant differences in febrile neutropenia or severe adverse events between the two treatment schedules.

Cite This Study

Satadeve et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3ce https://doi.org/10.1182/blood-2025-1687

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Implication

Randomized controlled trial compares consecutive and alternate day high-dose cytarabine schedules in AML, suggesting improved recovery and reduced hospital stay.

Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial from India

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial from India

Discussion

Member takes

Implication

Key Points

Cite This Study

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