December 8, 2025BloodOpen Access

Basal and stimulated intra-RBC and exported ATP and RBC adhesivity ex vivo in children with sickle cell disease

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Observational analysis found reduced RBC adhesivity in sickle cells with hypoxia, suggesting a role for ATP and PKR treatments.

Sickle cell disease exhibited altered red blood cells with increased exported ATP under hypoxia, despite PKR treatment.
Hypoxia led to a significant increase in exported ATP compared to normoxia, measured as 94.3 nM.
Experimental analysis under shear stress engaged RBC adhesion assessments using laminin-coated channels.
These findings underscore the complexity of ATP dynamics and adhesion properties of sickle red blood cells.

T. McMahon (2025) studied this question.

View Full Paper

Ask AI

Bookmark