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December 8, 2025BloodOpen Access

Venetoclax-based therapies in patients with Relapsed/Refractory T-cell prolymphocytic leukemia

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Authors

FVFrancisco VegaDSDeepa SampathAFAlessandra Ferrajoli

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Overview

Retrospective analysis shows venetoclax improves treatment response in R/R T-cell prolymphocytic leukemia, suggesting better outcomes with prolonged first remission.

Key Points

  • Overall response rate was 46% in patients treated with venetoclax-based therapies for relapsed T-PLL.
  • Among 35 patients, 23% achieved complete response, while median duration of response was 1.9 months.
  • Retrospective study of patients with R/R T-PLL receiving venetoclax as salvage therapy after prior treatments.
  • Highlights the urgent need for prospective trials to improve outcomes in patients with R/R T-PLL.

Cite This Study

Vega et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e20ahttps://doi.org/10.1182/blood-2025-3653
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of venetoclax in the treatment of relapsed/refractory light-chain amyloidosis2025
  2. 2Venetoclax plus inotuzumab ozogamicin for relapsed and refractory ALL: Results of a phase I trial2025 · 2 citations
  3. 3Venetoclax-obinutuzumab in frontline and R/R CLL: Outcomes compared to age- and sex-matched general population2025
  4. 4Phase II Results of ECOG-ACRIN EA9152: A multicenter study of liposomal vincristine (L-VCR) or vincristine sulfate (VCR) and venetoclax (VEN) in relapsed or refractory acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL)2025
  5. 5Venetoclax and decitabine in myeloproliferative neoplasm-blast Phase (MPN-BP): Results of enable, a gimema and airc-mynerva multicenter, Phase 2 trial2025 · 4 citations