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December 8, 2025Blood

Enhancing immunotherapy efficacy in myeloma with a novel dual-action mitochondrial toxic peptide that overcomes resistance and induces immunogenic cell death.

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Authors

CCColin CreanHLHolly LeeKLKelvin P. Lee

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Overview

Dual-action peptide enhances cytotoxicity and overcomes resistance in multiple myeloma, indicating improved T cell activation and immunogenic cell death.

Key Points

  • PP-k effectively induces immunogenic cell death in myeloma cells, enhancing immunotherapy efficacy.
  • Dual-action peptide reduced tumor cell growth with significant synergy when combined with Teclistamab.
  • Observational analysis of CD3 T cell activation and granzyme B levels revealed improvements with PP-k treatment.
  • Findings suggest a promising dual-function approach to overcome T cell exhaustion and resistance in myeloma.

Cite This Study

Crean et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e203https://doi.org/10.1182/blood-2025-3924
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  1. 1Ktx-1001, a potent, selective MMSET/NSD2 inhibitor, enhances immunomodulatory and immune-directed therapies in preclinical models of multiple myeloma2025
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  4. 4IgG2a-formatted 4-1BB agonism combined with S100A9 inhibition enhances T cell activation and tumor control in a preclinical model of multiple myeloma2025
  5. 5Antibody-mediated disruption of PD-L1 and CMTM6’s interaction in myeloid cells enhances immune activation to promote tumoricidal T cell expansion 24282025