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December 8, 2025BloodOpen Access

Spatial proteomics of the bone marrow reveals distinct Tumor–Immune niches in smoldering and relapsed myeloma and their remodeling in response to bispecific antibody and CAR-T therapy

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Authors

KFKane FosterDHDaniel Heilpern-MalloryMSMauro Nicollas Oliveira Silvério

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Overview

Analysis uncovers distinct immune niches in multiple myeloma, highlighting spatial interactions that inform immunotherapy outcomes.

Key Points

  • Immune remodeling occurs within the bone marrow in response to CAR T and bispecific antibody therapies.
  • Patient response correlates with spatial T cell infiltration and interactions among immune cell types.
  • Spatial proteomics leveraged to track changes in bone marrow microenvironment over time with therapy.
  • Findings suggest the significance of tumor-immune niches in predicting treatment efficacy in multiple myeloma.

Cite This Study

Foster et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1fchttps://doi.org/10.1182/blood-2025-3921
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone marrow spatial architecture predicts response duration in smoldering multiple myeloma patients receiving checkpoint inhibitor therapy2025
  2. 2Spatial biomarkers of CAR-T treatment response in relapsed refractory multiple myeloma2025
  3. 3The resistec study: Dissecting immune correlates of resistance and response to teclistamab in real-world multiple myeloma2025
  4. 4The dynamic landscape of immune environment for MM patients receiving T cell redirectiing therapies2025
  5. 5Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy2025