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December 8, 2025BloodOpen Access

Whole genome sequencing of cell-free DNA for assessment of minimal residual disease in high-risk smoldering multiple myeloma

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Authors

EHElizabeth HillBZBachisio ZicchedduTJTomáš Jelı́nek

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Overview

Longitudinal analysis shows cell-free DNA is effective for detecting minimal residual disease in high-risk smoldering multiple myeloma, suggesting improved monitoring options.

Key Points

  • Whole genome sequencing successfully identified minimal residual disease in high-risk smoldering multiple myeloma.
  • With a median follow-up of 66 months, findings showed that cfDNA detected MRD+ in 93% of cases compared to traditional methods.
  • Observational analysis conducted across multiple samples demonstrated the significance of tracking tumor fraction in plasma for disease progression.
  • The method offers a non-invasive alternative to marrow biopsies, highlighting the improved sensitivity of cfDNA in detecting MRD.

Cite This Study

Hill et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1f8https://doi.org/10.1182/blood-2025-3920
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