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December 8, 2025BloodOpen Access

Elevated circulating activated FOXP3+ regulatory T cell subset in patients with advanced chronic lymphocytic leukemia as a marker for severe infections during 1000 days of follow-up

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Prospective cohort study demonstrates higher activation of Tregs predicts serious infection risk in CLL, suggesting need for early interventions.

A higher percentage of activated Tregs is associated with an increased incidence of severe infections and mortality.
By day 365, 58% of patients with elevated aTregs experienced severe infections, indicating significant risk.
Patients were monitored through a prospective cohort study focusing on chronic lymphocytic leukemia and related infections.
Targeted therapy and chemoimmunotherapy showed no difference in infection rates, highlighting the importance of Treg levels.

Dreisinger et al. (2025) studied this question.

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Prospective cohort study demonstrates higher activation of Tregs predicts serious infection risk in CLL, suggesting need for early interventions.