Impact of Redox Imbalance and Mitochondrial Dysfunction on Neurotoxicity Induced by Perfluorooctanoic Acid in Male Wistar Albino Rats ( Rattus norvegicus )

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Discussion

Assessment reveals PFOA exposure increases neurotoxicity and oxidative stress in Wistar rats, indicating toxic effects on brain function.

Neurotoxicity is induced by PFOA exposure, evidenced by oxidative stress and mitochondrial dysfunction.
Statistical significance (p < 0.05) was found linking elevated oxidative stress markers to PFOA exposure.
Histopathological analysis revealed neuronal degeneration and reactive gliosis in the hippocampus following PFOA exposure.
Findings support the need for regulatory measures against PFOA and further toxicological evaluation.

Hongal et al. (2025) studied this question.

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