What type of study is this?

This is a Animal Study study (also classified as: In Vitro Study).

December 8, 2025Blood

Targeted lnp delivery of an RNA gene writer In Vivo enables generation of functional CAR-T cells

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Targeted LNP delivery shows 24% CAR-T expansion in vivo, highlighting potential for therapies in lymphomas and autoimmune diseases.

Expanding CAR-T cell generation in vivo, this approach enables up to 55% CD20 CAR+ T-cells during treatment.
Using targeted LNPs, an average of ~40% of T cells expressed the relevant gene, with minimal B cell delivery.
The study utilized humanized xenograft mouse models, enabling effective evaluation of CAR-T cell therapies.
These findings underscore the potential of RNA gene writers in overcoming challenges associated with traditional CAR-T therapies.

Cotta‐Ramusino et al. (2025) studied this question.

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