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December 8, 2025Blood

Performance of different large language models (LLMs) as decision support tools across various hematologic malignancies

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Authors

JAJeremy S. AbramsonANAjay K. NookaDSDavid M. Schuster

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Overview

Analysis shows that large language models yield good concordance with expert recommendations for hematologic malignancies, suggesting potential for decision support tools.

Key Points

  • Decision support tools exhibited good concordance with expert recommendations in hematologic malignancies, particularly non-Hodgkin lymphoma.
  • Aggregate competence scores ranged from 849 to 964 out of 1140 across 38 complex cases evaluated by large language models.
  • Assessment involved 3 large language models, with varying performance highlighted for specific cancer types such as multiple myeloma and non-Hodgkin lymphoma.
  • Findings indicate that language models may provide significant support in malignant hematology, emphasizing the need for careful human oversight.

Cite This Study

Abramson et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e13fhttps://doi.org/10.1182/blood-2025-4359
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