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December 8, 2025BloodOpen Access

Predictive value of red cell distribution width for SF3B1 mutation status in myelodysplastic neoplasms

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Authors

CHCyrus C. Hsia

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Overview

Retrospective analysis found RDW relates to SF3B1 mutations in MDS, suggesting value for molecular testing.

Key Points

  • RDW exhibited a trend toward association with SF3B1 mutations in MDS, indicating modest predictive value.
  • Among 165 MDS patients, 21 had SF3B1 mutations with 12.7% prevalence in the cohort.
  • Assessment using receiver operating characteristic curves revealed RDW's limited discrimination ability with AUC 0.632.
  • High platelet counts significantly correlated with SF3B1 mutations, supporting utility in prioritizing molecular testing.

Cite This Study

Cyrus C. Hsia (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e07bhttps://doi.org/10.1182/blood-2025-7401
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Also Consider

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  3. 3Clinical characteristics and molecular profiling of SF3B1-mutated myelodysplastic syndrome (MDS) in a real-world practice2025
  4. 4Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets2025 · 4 citations
  5. 5A Predictive Value of Red Blood Cell Distribution Width in Hodgkin Lymphoma in Iraqi Patients2025