Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Prognostic impact of co-occurring FLT3 mutations across molecular subgroups in intensively treated acute myeloid leukemia: Insights from real-world genomic data

View Full Paper
Ask AI
Bookmark
Share

Authors

YCYu-Sung ChangYWYuwen WangCYChi‐Yuan Yao

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows FLT3 mutations influence outcomes in acute myeloid leukemia, suggesting need for refined risk stratification.

Key Points

  • FLT3 mutations significantly impact overall survival in acute myeloid leukemia, with distinct co-mutations altering prognosis.
  • Patients with FLT3 ITD had a median overall survival of 16 months compared to 33 months for FLT3 wild type.
  • Multivariable Cox regression adjusted for age indicated treatment with FLT3 inhibitors was associated with improved survival outcomes.
  • Transcriptomic analysis revealed pathways related to DNA repair and fatty acid metabolism were notably altered in FLT3 mutant AML.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e043https://doi.org/10.1182/blood-2025-5249
View Full Paper
Ask AI
Bookmark
Share