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December 8, 2025BloodOpen Access

Duration of lymphopenia after CAR-T cell therapy is associated with increased risk of non-melanoma skin cancers and decreased survival

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Authors

MJMegan JonesGGGuido GhilardiSBStefan K. Barta

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Overview

Retrospective analysis reveals lymphopenia affects survival and increases non-melanoma skin cancer risk in B-cell lymphoma patients post CAR-T therapy.

Key Points

  • Lymphopenia post CAR-T therapy increases the risk of non-melanoma skin cancers and decreases survival rates.
  • Patients with lymphopenia have a higher incidence of non-melanoma skin cancers compared to those with immune recovery.
  • Assessment involved retrospective analysis of medical records of B-cell lymphoma patients receiving CAR-T therapy.
  • Significance highlights the need for monitoring lymphocyte counts to mitigate cancer risks post CAR-T treatment.

Cite This Study

Jones et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df61https://doi.org/10.1182/blood-2025-3728
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Also Consider

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  1. 1Risk of second primary malignancy following chimeric antigen receptor T-cell therapy: A real-world cohort study2025 · 1 citations
  2. 2Poor neutrophil recovery following CD19-targeted CAR-T cell therapy predicts inferior outcomes in adult patients with B-cell lymphoma2025
  3. 3Late immune effector cell-associated hematotoxicity (ICAHT) in patients with relapsed refractory large B-cell lymphoma receiving anti-CD19 chimeric antigen receptor T-cell therapy2025
  4. 4Risk of second primary hematological malignancy post chimeric antigen receptor T-cell therapy in diffuse large B-cell lymphoma: Propensity-matched analysis using trinetx database2025
  5. 5Long-term cardiovascular outcomes in patients with lymphoma who had early post-CAR-T cardiovascular events: A multi-center, international study2025