December 8, 2025Blood

Epidemiology and clinical characteristics of idiopathic multicentric castleman disease in Spain (ARCANA study): Prevalence cohort

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Discussion

Observational analysis identifies low iMCD prevalence in Spain, showing high comorbidity rates and responses to IL-6 blockade treatments.

Prevalence of iMCD in Spain is low at 0.51 cases per 100,000 inhabitants, with numerous exclusions due to diagnostic criteria.
73% of patients had prior treatments, with an 93.3% good response rate to IL-6 blockade therapies.
Multicenter observational study collected demographic data and clinical characteristics across 15 hospitals in Spain.
High rates of comorbid conditions were present, with hypertension and autoimmune disorders being the most common.

Ubieto et al. (2025) studied this question.

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