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December 8, 2025BloodOpen Access

A prospecitive, multicenter study of chidamide in adult patients with refractory primary immune thrombocytopenia

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RXRuirong Xu

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Overview

Randomized clinical trial showed that chidamide improved platelet count in patients with refractory ITP, indicating its potential therapeutic role.

Key Points

  • Chidamide improved overall response rates in patients with refractory immune thrombocytopenia, leading to better health outcomes.
  • At week 12, 43.3% of patients in the 5 mg group achieved an overall response, significantly higher than the 2.5 mg group.
  • Clinical trial revealed that the 5 mg dose yielded longer duration of response and better patient quality of life.
  • Chidamide was well tolerated, with common adverse events including fatigue and elevated liver enzymes.

Cite This Study

Ruirong Xu (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236dea3https://doi.org/10.1182/blood-2025-3043
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