Association between soluble immune biomarkers and monoclonal gammopathy of undetermined significance (MGUS) in three large cancer epidemiology cohorts with participants from underrepresented groups.
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Key Points
HGF levels significantly correlated with MGUS in several demographic groups, indicating its potential as a critical biomarker.
Logistic regression analysis showed an odds ratio of 1.66 per log pg/mL for HGF, with significance confirmed across multiple comparisons.
Assessment involved samples from three cancer epidemiology cohorts with a diverse racial makeup and various obesity levels.
Findings highlight the need for further exploration of biomarkers in MGUS, particularly in underrepresented groups and the role of IL6.
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Implication
Observational analysis revealed HGF is significantly associated with MGUS in diverse populations, suggesting biomarker importance in cancer development.