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December 8, 2025BloodOpen Access

Mutations in IDH1 and IDH2 portend a poor prognosis in adult patients with acute lymphoblastic leukemia

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Authors

HGHannah GoulartSLSanam LoghaviNDNaval Daver

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Overview

Retrospective analysis shows poor overall survival in adult acute lymphoblastic leukemia with IDH1 and IDH2 mutations, indicating need for new therapies.

Key Points

  • Patients with IDH1 or IDH2 mutations had lower overall survival rates of 43% compared to 68% in IDH wild-type.
  • The study included 449 adults with B-cell or T-cell acute lymphoblastic leukemia, assessing mutations and outcomes.
  • Retrospective analysis demonstrated significant prognostic implications for mutations in IDH1 and DNMT3A.
  • Novel therapies may improve outcomes for this high-risk cohort of acute lymphoblastic leukemia patients.

Cite This Study

Goulart et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de62https://doi.org/10.1182/blood-2025-1556
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IDH mutant MDS: Proposal for disease subset recognition based on molecular and clinical features, and the availability of targeted therapies2025
  2. 2IDH2 R172 mutation is associated with improved survival in IDH-mutated AML/MDS patients undergoing allogeneic stem cell transplantation: A geth-TC multicenter study2025
  3. 3Protein levels of isocitrate dehydrogenase 1 and 2 are prognostic and independent of mutation status in acute myelogenous leukemia2025
  4. 4Blast clearance dynamics and time to response across IDH1- and IDH2-mutated AML2025
  5. 5Treatment responses and survival of newly diagnosed older or unfit patients (pts) with IDH1/2-mutated Acute Myeloid Leukemia (AML): An analysis of the MARROW consortium2025