What type of study is this?

This is a Cohort Study study (also classified as: In Vitro Study, Validation Study).

December 8, 2025BloodOpen Access

Alpha-thalassemia and red blood cell heterogeneity in sickle cell trait: Interim findings from the achieving understanding of the natural history of sickle cell trait (AUNT) study

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Interim findings report increased risk of renal disease and venous thromboembolism in individuals with sickle cell trait.

Individuals with sickle cell trait exhibit varying red blood cell characteristics and potential complications.
One-third of individuals show α-globin gene abnormalities that affect hemoglobin levels and diseases.
Cross-sectional analysis across multiple centers aimed to assess clinical and laboratory findings in sickle cell trait.
Ongoing research may enable precision medicine approaches for sickle cell disease complications.

Madisetti et al. (2025) studied this question.

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