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December 8, 2025BloodOpen Access

Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease

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Higher mean flow velocities in the middle cerebral artery are linked to MRA-defined vasculopathy in sickle cell disease.
Mean flow velocities ranged 81 cm/s in patients with stenosis versus 67 cm/s without, p = 0.012.
Retrospective study of adults with sickle cell disease who underwent both transcranial Doppler and magnetic resonance angiography.
Highlights the need for longitudinal studies to support transcranial Doppler's role in neurosurveillance.

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Implication

Retrospective analysis shows transcranial Doppler correlates with MRA-defined cerebral vasculopathy in adults with sickle cell disease, suggesting a resource-efficient introductory imaging tool.

Cite This Study

Kazadi et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de05 https://doi.org/10.1182/blood-2025-4734

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Implication

Retrospective analysis shows transcranial Doppler correlates with MRA-defined cerebral vasculopathy in adults with sickle cell disease, suggesting a resource-efficient introductory imaging tool.

Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease

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Discussion

Implication

Cite This Study

Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease

Key Points

Discussion

Implication

Cite This Study

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